What Does Potentiation Mean?

What is the difference between synergism and potentiation?

The difference between the two concepts is that Synergism is talking about the interaction of two or more substances, while Potentiation is talking about a singular substance and how it may act when in a synergy relationship..

What is long term potentiation example?

Long-Term Potentiation (LTP) For example, if a mouse is placed in a pool of murky water, it will swim about until it finds a hidden platform to climb out on. With repetition, the mouse soon learns to locate the platform more quickly.

What is muscle potentiation?

Post-activation potentiation is a theory that purports that the contractile history of a muscle influences the mechanical performance of subsequent muscle contractions. … The peak torque of an isometric twitch in skeletal muscle is transiently increased after a brief maximum voluntary contraction.

What are the most common drug interactions?

This article focuses on 10 prevalent and potentially fatal drug interactions, listed in Table 3.Fluoxetine and Phenelzine. … Digoxin and Quinidine. … Sildenafil and Isosorbide Mononitrate. … Potassium Chloride and Spironolactone. … Clonidine and Propranolol. … Warfarin and Diflunisal. … Theophylline and Ciprofloxacin.More items…•

What is drug synergy?

Two or more drugs that individually produce overtly similar effects will sometimes display greatly enhanced effects when given in combination. When the combined effect is greater than that predicted by their individual potencies, the combination is said to be synergistic.

What is idiosyncrasy?

noun, plural id·i·o·syn·cra·sies. a characteristic, habit, mannerism, or the like, that is peculiar to an individual. … a peculiarity of the physical or the mental constitution, especially susceptibility toward drugs, food, etc.

What is an antagonistic?

: showing dislike or opposition : marked by or resulting from antagonism an antagonistic relationship factions antagonistic to one another.

What does synergistic mean?

When something is synergistic, it means various parts are working together to produce an enhanced result. If you’ve just heard a synergistic symphony, the musicians must have played very well together.

What happens during LTP?

LTP is the opposite of long-term depression (LTD). In LTP, after intense stimulation of the presynaptic neuron, the amplitude of the post-synaptic neuron’s response increases. The stimulus applied is generally of short duration (less than 1 second) but high frequency (over 100 Hz).

Why are drugs given in combination?

The rationale for combination therapy is to use drugs that work by different mechanisms, thereby decreasing the likelihood that resistant cancer cells will develop. When drugs with different effects are combined, each drug can be used at its optimal dose, without intolerable side effects.

What is potentiation of a drug?

(synergistic interaction) When the combined effect of two different drugs exceeds the expected additive effect of each of the drugs administered independently, one drug is said to potentiate the other. For example diazepam may potentiate the effect of alcohol.

What is potentiation effect?

Potentiation – This effect results when one substance that does not normally have a toxic effect is added to another chemical, making the second chemical much more toxic; for example: 0 + 2 > 2, not just 2. Antagonism – Antagonism is the opposite of synergism.

What does potentiate mean?

transitive verb. : to make effective or active or more effective or more active also : to augment the activity of (something, such as a drug) synergistically.

What is synergism like in your bloodstream?

Synergism is like a volcano in your bloodstream. Added 10/5/2019 9:03:20 PM. This answer has been confirmed as correct and helpful. S h. FROM THE CREATORS OF.

What are the effects of long term potentiation?

Long-term potentiation (LTP) in the hippocampus enhances the ability of a stimulus to produce cell firing, not only by increasing the strength of the EPSPs, but also by increasing the efficiency of the input/output (I/O) function of pyramidal neurons.

What is it called when two drugs are combined?

When two drugs are used together, their effects can be additive (the result is what you expect when you add together the effect of each drug taken independently), synergistic (combining the drugs leads to a larger effect than expected), or antagonistic (combining the drugs leads to a smaller effect than expected).

What is the purpose of long term potentiation?

a strengthening of synapses, which makes communication between neurons more likely. LTP is thought to be a crucial mechanism involved in memory formation.

What is an example of drug synergism?

Examples of synergism used to treat patients are when physicians treat bacterial heart infections with ampicillin and gentamicin and when cancer patients receive radiation and chemotherapy or more than one chemotherapy drug at a time.