What Are The Uses Of Atropine?

How does atropine work?

Atropine is a clinically relevant anticholinergic drug, which blocks inhibitory effects of the parasympathetic neurotransmitter acetylcholine on heart rate leading to tachycardia.

However, many cardiac effects of atropine cannot be adequately explained solely by its antagonism at muscarinic receptors..

Why Atropine is used in OP poisoning?

Atropine is given to poisoned patients to block muscarinic overstimulation. However, neuromuscular blocking agents (nicotinic acetylcholine receptor antagonists) are not currently used to prevent nicotinic overstimulation 57.

Do you give atropine or pralidoxime first?

Atropine, which is choice of drug to antagonise the muscarinic effects of organophosphates, is administered even before pralidoxime during the treatment of organophosphate poisoning.

Does atropine counteract poison?

Chemical Defense therapeutic area(s) Atropine Sulfate is used for treatment of nerve agent poisoning and organophosphate pesticide poisoning.

Does atropine raise blood pressure?

However, when given by itself, atropine does not exert a striking or uniform effect on blood vessels or blood pressure. Systemic doses slightly raise systolic and lower diastolic pressures and can produce significant postural hypotension.

When should atropine be used?

Atropine is the first-line therapy (Class IIa) for symptomatic bradycardia in the absence of reversible causes. Treatments for bradydysrhythmias are indicated when there is a structural disease of the infra-nodal system or if the heart rate is less than 50 beats/min with unstable vital signs.

What is atropine used for in emergency situations?

Although atropine treats bradycardia (slow heart rate) in emergency settings, it can cause paradoxical heart rate slowing when given at very low doses (i.e. <0.5 mg), presumably as a result of central action in the CNS.

How is atropine poisoning treated?

Specific treatmentGive physostigmine salicylate, 0.5–1 mg intravenously slowly over 5 minutes, with ECG monitoring.Repeat as needed to total dose of no more than 2 mg.

What is action of atropine?

Pharmacodynamics. Atropine reduces secretions in the mouth and respiratory passages, relieves the constriction and spasm of the respiratory passages, and may reduce the paralysis of respiration, which results from actions of the toxic agent on the central nervous system.

What are the side effects of atropine?

Common side effects of atropine sulfate include:dry mouth,blurred vision,sensitivity to light,lack of sweating,dizziness,nausea,loss of balance,hypersensitivity reactions (such as skin rash), and.More items…

Can atropine cause heart attack?

In patients with a recent myocardial infarction and/or severe coronary artery disease, there is a possibility that atropine-induced tachycardia may cause ischemia, extend or initiate myocardial infarcts, and stimulate ventricular ectopy and fibrillation.

How many doses of atropine can you give?

The dosing for Atropine is 0.5 mg IV every 3-5 minutes as needed, and the maximum total dosage for administration is 3 mg. Atropine should be avoided with bradycardia caused by hypothermia and, in most cases, it will not be effective for Mobitz type II/Second-degree block type 2 or complete heart block.

What does atropine do to the heart?

Atropine increases the heart rate and improves the atrioventricular conduction by blocking the parasympathetic influences on the heart.

Does atropine slow heart rate?

Atropine has complex effects on heart rate: At low doses, atropine blocks M1 acetylcholine receptors in the parasympathetic ganglion controlling the SA node. This decreases heart rate (Bernheim 2004). At higher doses, atropine also blocks M2 acetylcholine receptors on the myocardium itself.

How fast do you give atropine?

Atropine should be administered by rapid IV push and may be repeated every 3-5 minutes, to a maximum dose of 3 mg.