Which SSRI has less side effects?
Overall, citalopram appears to be the best-tolerated SSRI, followed by fluoxetine, sertraline, paroxetine, and fluvoxamine.
The latter 2 drugs are associated with the most side effects and the highest discontinuation rates because of side effects in clinical trials..
What is the best antidepressant with the least side effects?
These are generally well tolerated and have fewer side effects.Celexa (citalopram)Lexapro, Cipralex (escitalopram)Prozac (fluoxetine)Remeron (mirtazapine)Wellbutrin (bupropion)Zoloft (sertraline)
What is the most tolerated antidepressant?
For most patients, sertraline and escitalopram are more effective and better tolerated than other antidepressants.
Which antidepressant medication has the least side effects in the elderly?
SSRIs considered to have the best safety profile in the elderly are citalopram, escitalopram, and sertraline.  These have the lowest potential for drug-drug interactions based on their cytochrome P-450 interactions.